Abnormal Expression of Prolyl Oligopeptidase (POP) and Its Catalytic Products Ac-SDKP Contributes to the Ovarian Fibrosis Change in Polycystic Ovary Syndrome (PCOS) Mice

Polycystic ovary syndrome (PCOS) is an endocrine disorder and metabolic syndrome. Ovarian fibrosis pathological change in PCOS has gradually attracted people’s attention. In this study, we constructed a mouse model through the use of dehydroepiandrosterone. Sirius red staining showed that ovarian tissues mice had obvious fibrosis. Prolyl oligopeptidase (POP) serine protease N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) its catalytic product. Studies show abnormal expression activity POP Ac-SDKP are closely related to tissue It was found decreased ovaries mice. Further studies promoted matrix metalloproteinases 2 (MMP-2) transforming growth factor beta 1 (TGF-β1) granulosa cells. Hyperandrogenemia typical symptom PCOS. We testosterone induced low MMP2 high TGF-β1 overexpression treatment inhibited effect on vitro model. conclusion, Low changes fibrotic factors contribute by androgen.